Rajveer Singh Pawaiya: Molecular Pathology of Chemically-Induced & Spontaneous Animal Tumors


Description
DMBA-induced rat skin tumours were studied using molecular markers immunohistochemistry to elucidate different stages of chemical carcinogenesis and their evaluation in diagnosis of neoplasms in animals. Skin cancer produced through sequential histopathological changes: epidermal hyperplasia/hyperkeratinization, severe epidermal hyperplasia, papilloma, papillary carcinoma, squamous cell carcinoma/its metastasis in lungs and adnexal neoplasms. Among indices for proliferation markers (mitoses, AgNORs and PCNA), PCNA index was most reliable to differentiate benign papillomas with borderline papillary carcinomas. Immunohistochemically, the epidermal cells revealed p53, c-Myc and PCNA positive nuclear labelling for initiation and proliferation, strongly positive labelling for pre-malignant lesions and strong p53, c-Myc, PCNA and hTERT labelling for malignant transformation, and additional abnormal cadherin and fibronectin detection for invasion/metastasis. c-Myc was demonstrated in nuclei and cytoplasm of cancer cells by immuno-electron microscopy. Formalin-fixed animal and human tumour tissues showed overexpression of p53, c-Myc, PCNA and hTERT with loss of cadherin and fibronectin.
The crafty Pip Lincolne is back with her third book of sweet and whimsical projects. In Make Hey While the Sun Shines, she shows you 20 gorgeous things to make whatever your craftiness! There are bike seat covers made from vintage fabric, crocheted baubles to decorate your house (or car!), hand-printed gift bags and pretty decals to customise plates or mugs. More adventurous crafters might like to try the deer quilt (in either couch or cot size) or the handy bottle tote to store your drinks when you head out for the day. Making hey isn't just about sewing and craft though - there are also 5 pull-out recipe cards with delicious goodies to take on a picnic or just enjoy at home. Molecular Pathology of Chemically-Induced & Spontaneous Animal Tumors download ebook All of the projects have step-by-step instructions and illustrations to guide you through, and with comprehensive sections on sewing, crochet and knitting basics, Make Hey While the Sun Shines is perfect for anyone who is interested in handmaking their own beautiful things.
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Author: Rajveer Singh Pawaiya
Number of Pages: 244 pages
Published Date: 06 Jun 2012
Publisher: LAP Lambert Academic Publishing
Publication Country: Saarbrucken, Germany
Language: English
ISBN: 9783848410996
Download Link: Click Here
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